This marked the first time the club will win another club with over 4 goals in the league since Sir Alex Ferguson retired in 2013. The match was all but over in less than two minutes as debutanat Alexandre Jankewitz was shown a straight red card less than 2 minutes into the match for a lunging challenge on Scott McTominay.
Eight different players scored for United (including Jan Bednarek's own goal), breaking the all-time Premier League record of most goalscorers for the same team in a single match, set when seven Chelsea players scored in an 8–0 win over Aston Villa in December 2012.
United went on to score four goals in the first half, with Aaron Wan-Bissaka, Marcus Rashford and Edinson Cavani finding the net as well as a Jan Bednarek own-goal.
Five strikes followed in the second as Anthony Martial netted after coming on at the break before goals from Scott McTominay and Bruno Fernandes, and another Martial strike. Daniel James rounded off the scoring.
Southampton were reduced to 9 men after the referee, Mike Dean had no hesitation in pointing to the penalty spot after Man United's Martial took a tumble in the box and compounded Bednarek's misery by brandishing his second red card of the evening.
The Reds are now level on points with Manchester City ahead of their game against Burnley on Wednesday night, although Pep Guardiola's side do have two games in hand on the Old Trafford club.